30 Million Patients
with CLBP > 6 months
Majority Of Patients Do Not Achieve Adequate Pain Relief
Chronic low back pain patients is likely to have vertebrogenic pain
How Patients Describe Vertebrogenic Pain
Symptoms:
Pain during activity; bending, lifting, sitting, getting out
of bed or the car, boating, golfing, pickleball, gardening
SITTING
BENDING
ACTIVITY
LIFTING
Endplates as the
Source of Pain
In the past, there was no option to access
the nerve inside the spine so physician treated the disc or the facets. (MBB or RFA)
• New research shows vertebral endplates are more higher pain generators than the intervertebral discs.
• 30% of discs show evidence of pathologic innervations compared with 90% of adjacent endplates
• The basivertebral nerve causes pain across the vertebral endplates
BVN Ablation and the Intracept Procedure
The Intracept Procedure
• Same-day surgery, brief recovery
• Implant free
• Preserves overall spine structure
• Long-termpain relief after single
treatment (mean follow-up of 6.4
years)1-3
• Reduced utilization of injections3
• Proven safety profile4
Patient-Centric Outcomes
Nearly 80% of patients would choose this procedure again.
70% rated their condition as approved
Nearly 2/3 of patients report returning to a pre-LBP activity level
Clinical Evidence
15+ Years of Intracept® Clinical Evidence
Pilot Study
N=17
BVNA is safe
Effective
Led to SMART RCT
2007-2009
SMART Trial
N=225
Pivotal RCT
Effective v. sham
Long-term durability
2011-2014; 2019
INTRACEPT Trial
N=140
2nd RCT
Effective v. SC
Stopped early due to superiority of all
endpoints
2017-Present
Single-Arm Study
N=47
Typical spine practice
Effective
Reproducible
2018-Present
Regression Analysis
N=296
Objective biomarker
Vertebrogenic CLBP
Clinical + imaging to ID
BVNA candidates
2022